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Limiting alcohol and quitting smoking can help improve the effectiveness of this treatment

To continue to target lower costs, employers are eyeing alternative purchasing models and specialized obesity care vendors, Huang says, while continuing to pursue rebates and discounts and net cost transparency and pressing for tighter formulary management

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Severely symptomatic 2 IV bolus 150 ml 3% hypertonic over 20 min, check serum sodium Repeat IV bolus 150 ml 3% hypertonic over 20 min, check serum sodium Provide up to two additional 150 mL boluses, spaced 20 minutes apart, until a 5 mmol/L increase in sodium concentration is reached If symptoms improve after a 5 mmol/L increase is achieved, stop infusion and attempt to treat underlying cause Monitor sodium concentration every 6 hours If symptoms do not improve continue IV 3% hypertonic saline at a rate leading to an increase of 1 mmol/L/hr